Welcome to the Buchler Lab
We study the systems biology and evolution of oscillators in gene regulatory networks, which are essential for patterning, cell proliferation, and differentiation in biological systems. Our work is focused on oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources.
Edgar and Nick present at the Fungal Genetics Conference
Edgar Medina and Nick Buchler presented the lab’s latest work at the 30th Fungal Genetics Conference in Asilomar, CA on March 12th – 17th, 2019. ...
Congratulations to Edgar, a winner of the DeLill Nasser Award for Professional Development in Genetics!
Edgar was awarded a travel fellowship by the Genetics Society of America (GSA) to attend and present at the 30th Fungal Genetics Conference on March 12th-17th,...
Enhancer histone acetylation modulates transcriptional bursting dynamics of neuronal activity-inducible genes
Using CRISPR-mediate epigenome editing, this collaborative work between multiple labs shows that enhancer histone acetylation fine-tunes the activity-dependent transcription of Fos in neurons. Our lab...