Welcome to the Buchler Lab
We study the systems biology and evolution of oscillators in gene regulatory networks, which are essential for patterning, cell proliferation, and differentiation in biological systems. Our work is focused on oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources. We are affiliated with the Quantitative and Computational Developmental Biology (QCDB) initiative at NC State.
In silico evolution of an epigenetic switch in fluctuating environments
It has been suggested that epigenetic switches first evolved as a mechanism of bet-hedging and adaptation to fluctuating environments. To discern the evolutionary pressures that...
Fungal cell biology and the lateral gene transfer of a viral domain
Fun review article by our lab on how a viral KilA-N domain invaded the fungal ancestor, expanded through duplication, and became intimately associated with the...
Accelerated Bayesian inference from snapshots of single-cell transcripts
This paper is an improvement upon BayFish, our software for Bayesian inference of transcription dynamics from population snapshots of single‐molecule RNA FISH in single cells....